PMS Natural Remedies

Does Ginseng help reduce the severity of the common cold?

2010-12-26T12:20:00.000-08:00

In the pediatric population, upper respiratory infections are the most common childhood illness. With the majority of these infections being caused by a virus, there currently are no safe and effective antiviral medications available.

One common remedy that's been used to relieve symptoms of the cold is Ginseng. American Ginseng which is also known as Panax quinquefolius is purported to be effective in relieving cold symptoms in adult populations, but is it effective for children too?

A fairly recent study published in the journal, Pediatrics, attempted to answer this question [1]. The study itself involved using a specific preparation of Ginseng from CV Technologies called ColdFX.

The study authors reached the following conclusion:

CONCLUSIONS: Standard doses of ginseng were well tolerated and merit additional evaluation with regard to treatment of pediatric upper respiratory tract infection.

To find out more about natural remedies for colds, follow the link.

Reference:

Vohra S, Johnston BC, Laycock KL, Midodzi WK, Dhunnoo I, Harris E, Baydala L. Safety and tolerability of North American ginseng extract in the treatment of pediatric upper respiratory tract infection: a phase II randomized, controlled trial of 2 dosing schedules. Pediatrics. 2008 Aug;122(2):e402-10.

Ceroc Dance Classes?

2010-11-09T08:50:00.000-08:00

For those who're trying to get back into shape or simply shed a few extra pounds, participating in a fitness dance class can help with motivation.

Among popular fitness dance classes, many women and some men too are trying out Zumba or Ceroc Dancing. Some even view Ceroc Dance Classes as an opportunity to not only get fit but to socialize:

I was really pleased that the men had recognized Ceroc as a great opportunity to meet women. A man who knows how to dance is extremely desirable to many women and too many are scared to try, fearful of what their peers may think of them. As Ceroc is a dance that is generally led by men it was great to see these guys really keen to improve and become good dancers.

Low Mineral Intake in the Gluten-Free Diet?

2010-11-09T08:43:00.000-08:00

Elisabeth Hasselbeck - Gluten-Free

The Gluten-Free diet, a medical necessity for those with Celiac Disease, is gaining popularity among the general population. In part, this trend has been fueled by the popularity and support of the gluten-free diet among celebrities such as Victoria Beckham (Posh Spice), Zooey Deschanel, and The View's Elisabeth Hasselbeck, for example.

On a cautionary note, a research study from the UK suggests that the gluten-free diet may be deficient in some important minerals and dietary fiber [1].

From the study authors:

Individuals consuming a strict GFD (gluten-free diet) generally had similar intakes of energy and nutrients to those of comparison populations, but a higher proportion of carbohydrate intake was obtained from nonmilk extrinsic sugars and intakes of nonstarch polysaccharides were low. Compared with the UKWCS sample, female patients adhering to a GFD had lower intakes of magnesium, iron, zinc, manganese, selenium and folate. In male patients, intakes of magnesium and selenium were particularly low.

Summary:

The study authors found that the gluten free diet was high in sugar, low in minerals such as iron, zinc, manganese, selenium, magnesium, and folate, and low in dietary fiber.

References:

Aliment Pharmacol Ther. 2010 Aug;32(4):573-81. Epub 2010 Jun 4.

Supplements for losing weight

2010-08-10T23:13:00.000-07:00

Roughly 1/3 Americans meets the criteria for clinical obesity as determined by a body mass index of greater than 30 according to the CDC. If you take a second to think about that number, it's pretty startling, isn't it? For those who're trying to lose weight, it can be an enormous challenge. Though we all share some sense that it pertains to the basic principal of calories in / calories burned, there are many other factors involved.

One factor that's receiving attention lately are the emotional aspects of obesity. People often refer to using food--particularly food with high sugar or fat content to self-regulate their mood. When that type of cycle reinforces itself and repeats, it becomes an addiction.

In terms of losing weight, there are many options including making healthier diet choices. Sounds simple, right? True, but following through with healthier diets isn't often as easy as it sounds. Why is that? For the most part, people are creatures of habit. Changing these habits that took years to develop just isn't likely to happen over night.

Even with a healthy diet, you can generally expect to experience the plateau effect after about four to six months. At this point, your weight stabilizes and you have a harder time continuing losing weight. For this reason, regular exercise is a key component to achieving weight loss.

In our culture, people want quick fixes and fast results which is why weight loss supplements can seem so appealing. Some have caused serious health problems such as earlier versions of Hybrdoxycut and others contain ingredients that don't work at all.

If you're looking for an update on dietary supplements for weight loss, follow the link to find out which supplements work and which ones don't.

Omega-3 fatty acids and women's health

2010-07-21T22:33:00.000-07:00

Researchers have explored several potential health benefits of omega-3 fatty acids from fish oil. Some recent studies suggest that omega-3 fatty acid supplementation can improve lung function in athletes. In this particular study, participants who consumed 1000 mg of an omega-3 fatty acid supplement for 3 months experienced improvements in their FVC (20% forced vital capacity) and 10% in their maximum voluntary ventilation.

Other researchers have found that omega-3 supplements may reduce breast cancer risk in women. With long-term and current use, this risk maybe reduced by 32%. Further research is required in this are to confirm these results.

Another recent study found that omega-3 fatty acid consumption in women was linked to a lower risk of endometriosis with a reduced risk of up to 22% compared to those who consumed the least amount.

What is the Zumba dance workout?

2010-07-12T09:24:00.000-07:00

Though I'll never quite understand what sparks new fitness trends, I imagine it has a fair amount to do with a successful marketing campaign. Right now, one of the hottest or most popular workout trends is the Zumba Dance Workout.

The Zumba dance workout just might be the biggest fitness fad since Tai Bo or aerobics. Leveraging the popularity of Dancing with the Stars, it incorporates Latin dance moves with a cardio workout.

Have you tried Zumba yet?

How to manage your RSS feeds?

2010-07-06T21:44:00.000-07:00

One common question that people who read blogs find themselves asking is what is the best way to manage RSS Feeds? If you don't already know what an RSS Feed is, it's basically a way of subscribing to your favorite blogs. In the past, the only way to keep track of your favorite sites was to bookmark them which is far less convenient.

Though there are tons of old Feed readers which are available for free. There's also another free options that's far more convenient to use. Feedly is a free add-on for Firefox and other browsers that let's you subscribe and keep track of your favorite RSS Feeds.

What's different about Feedly? To start with, it lets you organize your blog feeds by categories in a convenient magazine-like start page. Try it today for yourself and see if it makes organizing your favorite websites easier than bookmarks.

5 Healthy Recipes you should try...

2010-07-03T17:15:00.000-07:00

For those who're looking to get back into shape, making healthy lifestyle changes can go a very long way. Typically, this involves two basic premises--eating better and starting an exercise program. Though there are plenty of options for exercise programs, it can be a challenge to find healthy recipes.

If healthy recipes are what you're looking for, here are five great recipes from The Healthy Irishman.

Chicken meatball boats
Sesame crusted turkey & spinach salad
Paleo pulled pork wrap
Paleo 'fried' chicken 'n' strawberry salad
Grilled cumin lamb kabobs.

St John's wort for treating PMS?

2010-03-04T13:35:00.000-08:00

St Johns wort for treating premenstrual syndrome?

A very recent study was published in the journal, CNS Drugs, which studied the effectiveness of Hypericum perforatum (St John's wort) in treating premenstrual syndrome (PMS).

The intervention group received Hypericum perforatum tablets 900 mg/day (standardized to 0.18% hypericin; 3.38% hyperforin) for two menstrual cycles.

Results:

Hypericum perforatum was statistically superior to placebo in improving physical and behavioural symptoms of PMS (p < 0.05). There were no significant effects of Hypericum perforatum compared with placebo treatment for mood- and pain-related PMS symptoms (p > 0.05).

In short, St. John's wort was effective at improving physical and behavioural symptoms, but not effective for mood or pain symptoms.

***Talk to your doctor about using St. John's wort for treating your PMS symptoms. St. John's wort should not be taken by those who are already taking antidepressant medication.

St. John's wort can interact with a number of different medications (psychiatric, seizure, blood thinners among others), so make sure you tell your doctor that if you're taking this supplement.

reference:

Canning S, Waterman M, Orsi N, Ayres J, Simpson N, Dye L. The efficacy of Hypericum perforatum (St John's wort) for the treatment of premenstrual syndrome: a randomized, double-blind, placebo-controlled trial. CNS Drugs. 2010 Mar 1;24(3):207-25

St. John's Wort for Hot Flashes in perimenopausal women?

2009-02-06T09:20:00.000-08:00

St. John's Wort for Hot Flashes in perimenopausal women?

Menopause or the 'climacteric' is often defined as the cessation of menstration which typically occurs in women between the ages of 45 and 55. Essentially, this means that when women 'hit' menopause, that this represents their loss of fertility.

Though menopause is a biological process and not a disease, there are symptoms that women typically experience during this change. Hot flashes themselves can be particularly disturbing to many women. The results of a recent Canadian study suggest that hypericum perforatum (St. John's wort) may improve quality of life and reduce sleep symptoms associated with menopause (Al-Akoum et al, 2009). Additionally, St. John's wort reduced the frequency of hot flashes in perimenopausal women--but these results were not statistically significant.

What dosage of St. John's wort was used in this particular study? For this study, they used ethanolic St. John's wort extract (900 mg TID) which essentially means 900mg administered three times per day. ***This dose is in excess of more typical doses of 900 mg/day.

If you are a symptomatic perimenopausal women who is considering trying St. John's wort--keep in mind that there are potential side effects from this herbal remedy and that St. John's wort may interact with medication that you're currently taking.

The study authors conceded that the results of this particular study need to be confirmed in larger clinical trials.

Reference:
Al-Akoum M, Maunsell E, Verreault R, Provencher L, Otis H, Dodin S. Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause. 2009 Feb 3.

Mind & Body Solution for PMS--Free E-Book | Jarret Morrow, M.D.

2009-01-24T10:57:00.000-08:00

Mind and Body Solution for PMS

A Patient’s guide to the latest knowledge about Premenstrual Syndrome (PMS) from University Health Industries

Part 1: About PMS

What are PMS and PMDD?
What causes PMS?
What are the symptoms of PMS?
What are the risks of PMS and PMDD?
How can I tell if I have PMS?
What can I do to manage my symptoms?
What medical treatments are available?
How effective are Selective Serotonin Reuptake Inhibitors (SSRIs) for the treatment of PMS?
What is the effectiveness of gonadotropin releasing hormone analogues (GnRHa) therapy in treating PMS?
Is bright light therapy effective for treating the depression associated with premenstrual dysphoric disorder?

Part 2: About Zenstral

What is Zenstral PMS™?
Who should take Zenstral PMS™?
What are the ingredients?
How does Zenstral PMS™ work?
What is evidence based medicine?
What is a meta-analysis?
What scientific evidence was used in formulating Zenstral PMS™?
What other nutraceuticals are available from UHI?
Who should not take Zenstral PMS™?
How much should I take?
When will it start to work?
What are the possible side effects?
What is the NPA TruLabel Program?
What is your guarantee?
Who is University Health Industries, Inc.

Part 1: About PMS

Understanding PMS is one of the most important things you can do to manage your symptoms. In this booklet, we present the known facts about PMS, an overview of treatment options, and current independent research that supports the use of Zenstral PMS™ for relieving PMS and PMDD.

What are PMS and PMDD?

Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), a more severe form of PMS, are both very common and potentially debilitating conditions from which many women suffer. Hormonal changes following ovulation trigger a group of disruptive symptoms that appear approximately 14 days before your period. PMS and PMDD affect an estimated 40 million women in the United States, with more than 5 million requiring medical treatment.

What causes PMS?

Though the exact cause of PMS is not completely understood, it appears that the hormones progesterone, estrogen and testosterone are involved, along with changes in the level of the brain chemical serotonin. Nutritional deficiencies in magnesium or vitamin B6, hormonal changes, neurotransmitter activity, diet, and stress have all been implicated in the etiology of PMS.1,2

What are the symptoms of PMS?

Most women feel some discomfort before their periods. But if you have PMS, you may feel so anxious, depressed, or uncomfortable that you can't cope at home or at work. Common symptoms of PMS include:

Physical Symptoms

Breast tenderness (mastodynia)
Cramping
Swollen hands or feet
Weight gain
Headaches
Bloated abdomen
Constipation
Joint pain
Fatigue
Acne

Psychological Symptoms

Irritability
Angry outbursts
Low self-esteem
Anxiety
Confusion
Difficulty concentrating
Mood swings
Crying spells
Decreased libido
Depression

Symptoms usually stop or taper off soon after your period begins, and you may be symptom free until about two weeks before your next period.

What are the risks of PMD and PMDD?

PMS and PMDD are not mere inconveniences. These conditions can adversely impact a woman’s personal, professional, and financial success. Women suffering from PMS are at increased risk of depression, absenteeism from work, strained relationships, reduced productivity, and worsening of medical conditions such as epilepsy, asthma, fibromyalgia, multiple sclerosis, or migraine headache during specific phases of their menstrual cycles.

How can I tell if I have PMS?

According the American College of Obstetricians and Gynecologists (ACOG), you may have PMS if

    * Your PMS symptoms occur only during the last two weeks of your cycle.
    * the symptoms are sufficiently uncomfortable to impair your quality of life.
    * other disorders that may be mistaken for PMS have been excluded.

If you suspect you have PMS, ACOG recommends keeping a daily log of your symptoms for two or three consecutive months to help in diagnosis. It’s important to talk with your doctor to confirm your diagnosis and rule out other possible causes of your symptoms, such as depression, migraine headaches, seizure disorders, irritable bowel syndrome, chronic fatigue syndrome, or allergies.

What can I do to manage my PMS symptoms?

Women can often manage the symptoms of premenstrual syndrome by making changes in the way they eat, exercise, and approach their daily lives. To reduce your discomfort, try implementing as many of the suggestions below as you can.

Dietary Tips for Controlling PMS

    * Eat smaller, more frequent meals to reduce bloating and the sensation of fullness.
    * Eat complex carbohydrates such as whole grain breads, pasta, and cereals.
    * Cut back on sugar and fat in your diet.
    * Avoid salt for the last days before your period to reduce bloating and fluid retention.
    * Avoid caffeine intake to feel less tense and irritable.

    * Choose foods rich in calcium.
    * Increase consumption of dietary fiber.

Lifestyle Tips for Controlling PMS

    * Get aerobic exercise. Regular daily exercise will help improve your overall health and can alleviate     symptoms such as fatigue and a depressed mood.
    * Ensure adequate sleep—about eight hours per night.
    * Attempt to schedule stressful events for the week after your period.
    * Maintain a regular schedule of meals, bedtime, and exercise.
    * Practice deep-breathing exercises to help reduce headaches, anxiety, or trouble sleeping.
    * Avoid smoking cigarettes.

What medical treatments are available for PMS and PMDD?

There are four types of prescription drugs used for PMS/PMDD:

   1. Antidepressants that act on serotonin, including fluoxetine, sertraline, and paroxetine.The FDA has recently ordered makers of several antidepressants to issue black box warnings that patients on these medications should be closely monitored for “clinical worsening, suicidality, or unusual changes in behavior.”
   2. Agents that suppress ovulation, such as danazol, transdermal estradiol patches, and some oral contraceptives. These medications carry risks for serious side effects and can be very expensive.
   3. Other psychotropics to reduce anxiety, such as alprazolam and other anxiolytic benzodiazepines. Since alprazolam has a very short half-life, there is a risk of addiction for patients who are started on this medication.
   4. Spironolactone, a diuretic that is only available by prescription. It has proven effective in reducing premenstrual fluid retention, but doesn’t address the other symptoms of PMS.

How effective are selective serotonin reuptake inhibitors (SSRI’s) for the treatment of PMS?

SSRI’s are a class of drugs used in the treatment of depression, anxiety, and personality disorders. Patients can experience many side effects from the use of these medications including weight changes, increase in anxiety, suicidal thoughts, and sexual dysfunction. A study published in the Cochrane Database concluded that there is very good evidence to support the use of selective serotonin reuptake inhibitors in the management of severe PMS. However, withdrawals due to side effects were 2.5 times more likely to occur in the treatment group than in the placebo group.3

What is the effectiveness of using gonadotropin releasing hormone analogues (GnRHa) to treat PMS?

GnRH analogues work to stop menstrual periods by decreasing estrogen production. A recent meta-analysis published in the British Journal of Obstetrics and Gynecology concluded that GnRHa treatment appears to be an effective option in the management of PMS.4 Unfortunately, patients who take these analogues can experience several serious side effects, including menopausal type symptoms such as hot flashes, mood swings, vaginal dryness, and increased LDL cholesterol and bone loss.

Is bright light therapy effective for treating the depression associated with premenstrual dysphoric disorder?

Light therapy consists of exposure to full-spectrum light for a prescribed amount of time. A recent meta-analysis of bright light therapy published in the American Journal of Obstetrics and Gynecology concluded that “the current evidence justifies neither enthusiastic dissemination nor confident rejection of this therapeutic modality.”5 Essentially, this suggests that more research is required to study the potential benefit of this treatment for PMS.

Part 2: About Zenstral PMS ™

Zenstral PMS from University Health Industries

[Testimonial]

“I want to thank you for all of your help. I have had the most terrible PMS with every symptom possible. Zenstral PMS has made all the difference! I have none of the symptoms: no headache, cramps, irritability, mood swings, or aches. This works! Thanks so much for this product!"

- Debbie W, North Carolina.

What is Zenstral PMS™?

Zenstral PMS™ is an innovative blend of natural compounds that are scientifically proven to reduce the symptoms of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). Unlike other PMS treatments, Zenstral addresses both the physical and psychological symptoms of PMS/PMDD in one convenient product, without the risk of dangerous side effects.

Using the principles of evidence based medicine, our physicians and pharmacologists formulated Zenstral PMS™ after months of reviewing the results of university research studies worldwide. The result is a powerful nutraceutical that is as effective as other PMS remedies—and safer.†

Who should take Zenstral PMS™?

Zenstral PMS™ is recommended for women suffering from

    * general PMS-related symptoms
    * cyclical mood symptoms of PMS including irritability, tension, depression
    * lower back and joint pain associated with PMS
    * fluid retention associated with PMS
    * breast tenderness associated with PMS

What are the ingredients in Zenstral PMS™?

Each caplet contains 20 mg of Vitex agnus castus (.3% casticin), 200 mg of magnesium oxide (MgO), and 50 mg of vitamin B6 (pyroxidine)..

The Vitex agnus castus (VAC) compound used in Zenstral is casticin, a flavonoid from the chasteberry. This is the same substance used in the clinical studies that show Vitex agnus castus to be effective. Nearly all other products on the market standardize to agnuside, a terpene compound from the chasteberry tree.

How does Zenstral PMS™ work?

The natural compounds in Zenstral work on many of the biochemical mechanisms that contribute to PMS:†

   1. Vitex Agnus Castus Extract (VAC): VAC acts on the hypothalamic-pituitary-adrenal (HPA) axis, a set of complex interactions between three hormone-producing organs. It also reduces stress-induced prolactin levels by simulating the effects of dopamine in the brain (dopamine agonist).6 In addition, VAC has been found to elevate beta-endorphin and opiod levels, naturally occurring substances that decrease pain and create a feeling of calm and well-being.7,8
   2. Magnesium: Low levels of red-cell magnesium have been correlated with symptoms of PMS.9 This is the rationale for supplementation with magnesium and has resulted in a number of studies on magnesium supplementation in women suffering from PMS.
   3. Vitamin B6: Also called pyroxidine, vitamin B6 has a positive effect on levels of neurotransmitters such as serontonin, norepinephrine, histamine, dopamine, and taurine.10

What is evidence-based medicine?

Evidence based medicine (EBM) involves examining a broad spectrum of evidence—such as meta-analyses, systematic reviews of existing research, randomized controlled trials, cohort studies, and other methods of inquiry—to make decisions about patient care and treatment.

EBM is rapidly becoming the new paradigm in health care, replacing the older authority-based model where the value of a medical treatment (and sometimes its availability) was based on the work of a limited number of experts.

To learn more about evidence based medicine, a non-profit organization called the Cochrane Collaboration (www.cochrane.org) is an excellent place to begin.

What is a meta-analysis?

A meta-analysis involves collecting data from many similar research studies, then analyzing the pooled data for statistical significance.

What evidence was used in formulating Zenstral PMS™?

Below is a representative sample of the scientific evidence used in formulating Zenstral PMS™:

Vitex Agnus Castus Extract (VAC)

A recent double-blind, randomized controlled trial published in the British Medical Journal demonstrated a 52 percent reduction in PMS symptoms in women treated with dry extract of agnus castus fruit.11 Similar results were obtained in another study published in the Archives of Gynecology and Obstetrics.12

Another recent study found Vitex agnus castus extract to be as effective as fluoxetine for the treatment of PMDD, a more severe form of PMS. The authors reported that 57.9 percent of patients responded to VAC extract in the treatment of this disorder, and also found that VAC extract was more effective than fluoxetine in treating the physical symptoms of PMDD.13

German health authorities have approved the use of chasteberry for three gynecological conditions: menstrual cycle irregularity, premenstrual syndrome (PMS), and mastodynia (breast pain).14

Magnesium

A recent randomized, double-blind crossover study concluded that magnesium works synergistically with vitamin B6 to relieve anxiety symptoms associated with PMS.15

Vitamin B6

The British Medical Journal did a meta-analysis of vitamin B6 in the treatment of PMS and concluded that it was likely to be beneficial in treating premenstrual symptoms and premenstrual depression.16

Who should not take Zenstral PMS™?

Consult a physician before use if you are pregnant, nursing, taking birth control pills, have a hormone-sensitive medical condition such as breast cancer, or are taking dopamine-related medications.

How much should I take?

The typical dosage is one caplet twice daily. Take Zenstral™ every day of the month, not only when you’re having symptoms. It needs to reach and maintain therapeutic levels in the body to work.

When will it start to work?

With daily use, Zenstral™ will reach therapeutic levels in your system within three to four weeks, so you should feel relief by the second cycle. In contrast, prescription antidepressants take at least a month to start working and don’t address the physical symptoms of PMS.

What are the possible side effects?

No serious side effects have been reported for the ingredients in Zenstral PMS™. Data from clinical trials, post-marketing surveillance studies, spontaneous reporting systems, manufacturers, and herbalist organizations indicate that the compounds in Zenstral PMS™ are generally well tolerated, and that any adverse events following VAC treatment are mild and reversible.17 Possible side effects include nausea, gastrointestinal discomfort, headache, or pruritus.11,12,13,15,16,17,18

Consult a physician if you experience any of these side effects or use this product longer than six months. Discontinue use and consult a physician if an allergic reaction occurs.

No drug interactions have been reported. However, because of Zenstral’s mode of action, consult your physician before use if you are taking dopamine-related medications.

What is the NPA TruLabel Program?

The Natural Products Association (NPA) TruLabel program is the industry's most expansive and successful self-regulatory program.

University Health Industries and other NPA members voluntarily pay for random monitored tests of their products by independent laboratories. If a test reveals any deficiency in product quality or accuracy in labeling, NPA immediately alerts the member company and expects it to take corrective action. NPA revokes the membership of any company that does not comply.

What is your guarantee?

University Health Industries’ products are backed by our 100% money-back guarantee for first-time orders. If for any reason you are not completely satisfied with your order, simply return it within 30 days and we'll issue you a full refund of your purchase price, less shipping and handling.

Who is University Health Industries, Inc?

Every year, research labs around the globe identify and test natural compounds with the potential to improve human health—yet more than 98% of these discoveries are never commercialized for the benefit of the public.

University Health Industries, Inc. (OTC:UVHI), in collaboration with universities worldwide, researches natural compounds with clinically proven efficacy, identifies those with the greatest potential for enhancing human life, then develops them into patented nutraceutical products for treating common chronic ailments.

Our mission is to make the latest clinical discoveries in natural compounds available to consumers, delivered in patented pharmaceutical-grade formulations with guaranteed quality and potency.

UHI is a proud American company with offices and manufacturing facilities in Boca Raton, Florida. All of our products are GMP-approved and made in the United States to ensure they adhere to standards the American public can trust.

What other nutraceuticals are available from UHI?

UHI will introduce three new products in the coming weeks , each developed with the same quality and efficacy standards as Zenstral PMS™:

    * Arthroleve ULT™ for bone and joint pain †
    * Premium SAMe ULT™ for mood support†
    * Cold & Flu RMD™ for immune system support and relief from the common cold†

Our physicians and pharmacologists are hard at work creating additional evidence-based nutraceutical products. Visit the UHI Web site at universityhealthindustries.com for updates, or request new product announcements by email at zenstralpms.com.

We welcome your feedback. Please contact us at 1 888 575 1700 or send an email to customercare@arthroleve.com with your suggestions, questions, and comments.

References

1. Mortola J. Premenstrual syndrome-pathophysiologic considerations. N Engl J Med. 1998; 338:256-7.

2 Chrousos GP, Torpy DJ, Gold PW. Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: Clinical implications. Ann Intern Med. 1998;129:229-40.

3 Wyatt KM, Dimmock PW, O’Brien PM. Selective serotonin reuptake inhibitors for premenstrual syndrome. Cochrane Database Syst Rev. 2002;(4):CD 001396.

4 Wyatt KM, Dimmock PW, Ismail KM, Jones PW, O’brien PM. The effectiveness of GnRHa with and without ‘add-back’ therapy in treating premenstrual syndrome: a meta analysis. BJOG, 2004 Jun;111(6):585-93.

5 Krasnik C, Montori VM, Guyatt GH, Heels-Ansdell D, Brusse JW; Medically Unexplained Syndromes Study Group. The effect of bright light therapy on depression associated with premenstrual dysphoric disorder. Am J Gynecol. 2005 Sep;193(3 Pt 1):658-61.

6 Merz PG, Gorkow C, Schordter A, Rietbrock S, Sider C, Loew D, Dericks–Tan JSE, Taubert HD. The effects of special Agnus castus extract (BP 109E1) on prolactin secretion in healthy male subjects. Exp Clin Endocrinol Diabetes. 1996;104:447-53.

7 Brugisser R, Burkard W, Simmen U, Schaffner W. Untersuchungen an Opiod-Rezeptorin mit Vitex agnus-castus L. Z Phytother. 1999;20:140-58.

8 Samochowic L, Glaesmer R, Samochowic J. EifluBvon Monchspfeffer auf die konzentration von beta-Endorphin im Serum weiblicher Ratten. Arztez Naturheilverfahren. 1998;39:213-215.

9 Rosenstein DL, Elin RJ, Hosseini JM, et al. Magnesium measures across the menstrual cycle in premenstrual women. Biol Psychiatry. 1994;35:557-61.

10 Schindler R, Thoni H, Classen HG. The role of magnesium in the generation and therapy of benign muscle cramps. Combined in vivo/in vitro studies on rat phrenic nerve-diaphragm preparations. Arneimittel-Forschung. 1998;48:161-66.

11 Schellenberg, et al. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomized, placebo controlled study. BMJ. 2001;322;134-7

12 Berger D, Schaffner W, Schrader E, Meier B, Brattstrom A. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS). Arch Gynecol Obstet. 2000; 264:150-53.

13 Atmaca M, Selahattin K, Texcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Human Psychopharmacol Clin Exp. 2003;18:191-5.

14 Blumenthal M, Busse WR, Goldberg A, et al. The complete German Commission E. monographs: therapeutic guide to herbal medicines. Austin TX. American Botanical Council. 1998, p1694.

15 De Souza M, Walker A, Robinson P, Bolland K. A synergistic effect of daily supplement for 1 month of 200mg magnesium plus 50mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. Journal of Womens Health & Gender-Based Medicine. 2000 Mar;9(2)131-3.

16 Wyatt K, Dimmock P, Jones P, Shaughn O’brien PM. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systemic review. BMJ. 1999; 318:1375-81.

17 Daniele C, Thompson J, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf. 2005;28(4):319-32.

18 Walker A, De Souza M, Vickers M, Abeyasekera S, Collins M, Trinca L. Magnesium supplementation alleviates premenstrual symptoms of fluid retention. Journal of Women’s Health. 1998 Nov;7(9):1157-65.

19 Proctor M, Murphy P. Herbal dietary therapies for primary and secondary dysmenorrhoea (Cochrane review). The Cochrane Library, Issue 2, 2002. Oxford: update software.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Role of Folic Acid, Vitamin B12, and Vitamin B6 in cancer prevention?

2008-12-08T13:33:00.000-08:00

Folic acid, Vitamin B12, and Vitamin B6 in cancer prevention?

One common topic or area of concern for my blog readers is regarding cancer prevention. For some, vitamins including folic acid, B12, and B6 are thought to have a possible role in preventing certain types of cancers in women. A recent trial published in the Journal of American Medicine Association (JAMA), explored the potential cancer preventing benefits of these vitamins in (5442) female health professionals over the age of 42 (Zhang et al, 2008).

INTERVENTION: Daily supplementation of a combination of 2.5 mg of folic acid, 50 mg of vitamin B(6), and 1 mg of vitamin B(12) (n = 2721) or placebo (n = 2721).

MAIN OUTCOME MEASURES: Confirmed newly diagnosed total invasive cancer or breast cancer.

RESULTS: A total of 379 women developed invasive cancer (187 in the active treatment group and 192 in the placebo group). Compared with placebo, women receiving the active treatment had similar risk of developing total invasive cancer.

Conclusion: Unfortunately, despite the large number of participants in this trial as well as the relatively long duration of the trial (7.3 years), this study failed to find any benefit of folic acid, Vitamin B12, or Vitamin B6 in the prevention of breast or total invasive cancer in women.

The results of this particular study contradict the results of a previous study that suggested that Vitamins B6 and B12 may reduce the risk of breast cancer, particularly in postmenopausal women:

Vitamin intake and breast cancer risk

Reference:

Zhang SM, Cook NR, Albert CM, Gaziano JM, Buring JE, Manson JE. Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. JAMA. 2008 Nov 5;300(17):2012-21.

Cognitive behavioral therapy (CBT) for PMS?

2008-11-05T15:14:00.000-08:00

Cognitive behavioral therapy (CBT) for PMS?

Estimates of the prevalence of premenstrual syndrome (PMS) range from between 3-30% of women of reproductive age, depending on how it is defined. A recent article (meta-analysis), published in the journal, Psychotherapy and Psychosomatics (Busse et al, 2008), explored the efficacy of cognitive behavioral therapy for treating PMS.

Cognitive Behavioral therapy (CBT) is form of psychotherapy. It is based on the assumption that cognitive structures shape the way people react and adapt to a variety of situations or stressors in their lives.

If you suffer from PMS, you may want to explore treatment with CBT (discuss with your physician), particularly if you have prominent symptoms of anxiety or depression.

Results:

Reduces anxiety
Reduces depression
Possible benefit on behavioral changes
Possible benefit on interference of symptoms on daily living

Study conclusion:

Low quality evidence from randomized trials suggests that cognitive behavioural therapy may have important beneficial effects in managing symptoms associated with premenstrual syndrome.

Reference:

Busse JW, Montori VM, Krasnik C, Patelis-Siotis I, Guyatt GH. Psychological Intervention for Premenstrual Syndrome: A Meta-Analysis of Randomized Controlled Trials. Psychother Psychosom. 2008 Oct 14;78(1):6-15.

Vitamin B6 (Pyridoxine) for PMS--New study results!

2008-10-28T09:10:00.000-07:00

Premenstrual syndrome is a very common condition that affects women of reproductive age. A recent study was published in the Indian Journal of Physiology and Pharmacology (Sharma et al, 2007), which compared Vitamin B6 (pyridoxine) to both Bromocriptine and placebo.

Bromocriptine is a dopine agonist that is usually used for the treatment of pituitary tumors as well as Parkinson's disease.

Interventions:

Bromocriptrine 2.5 mg twice a day and pyridoxine 100 mg/day.

Results:

Both Bromocriptine and Vitamin B6 (pyridoxine) showed a significant reduction in mean premenstrual symptom scores.

Conclusions:

It is concluded that both the drugs are effective for treatment of premenstrual syndrome but, pyridoxine showed significantly higher response rate and lesser incidence of side effects than bromocriptine.

*Vitamin B6 (pryidoxine) is found in the patent-pending Zenstral PMS formulation. For natural PMS relief, click the link.

Reference:

Sharma P, Kulshreshtha S, Singh GM, Bhagoliwal A. Role of bromocriptine and pyridoxine in premenstrual tension syndrome.Indian J Physiol Pharmacol. 2007 Oct-Dec;51(4):368-74.

Cigarette smoking increases risk of PMS?

2008-10-14T15:11:00.000-07:00

Moderate to severe symptoms affect approximately 20% of premenopausal women. A recent study, published in the American Journal of Epidemiology (2008) explored whether or not smoking cigarettes is involved in the etiology of premenstrual syndrome (Bertone-Johnson et al, 2008).

Conclusions:

"Results suggest that smoking, especially in adolescence and young adulthood, may increase risk of moderate to severe PMS. These findings may provide an additional incentive for young women to avoid cigarette smoking."

Reference:

Bertone-Johnson ER, Hankinson SE, Johnson SR, Manson JE. Cigarette smoking and the development of premenstrual syndrome. Am J Epidemiol. 2008 Oct 15;168(8):938-45. Epub 2008 Aug 13.

Related posts:

From Dr. Nicole's Kitchen Table Medicine: How to quit smoking...

Zenstral PMS --The Peace of Mind and Body Solution

2008-05-28T08:56:00.000-07:00

Zenstral PMS--Click this link for a Free Trial Offer!

Effect of a proprietary Magnolia and Phellodendron extract on stress levels

2008-05-23T06:19:00.000-07:00

Effect of a proprietary Magnolia and Phellodendron extract on stress levels

A recent study published in the Nutrition Journal suggests that Relora may after some relief from anxiety for premenopausal women.

"BACKGROUND: Recent research has established correlations between stress, anxiety, insomnia and excess body weight and these correlations have significant implications for health. This study measured the effects of a proprietary blend of extracts of Magnolia officinalis and Phellodendron amurense (Relora) on anxiety, stress and sleep in healthy premenopausal women. "

"CONCLUSION: This pilot study indicates that Relora may offer some relief for premenopausal women experiencing mild transitory anxiety. There were no safety concerns or significant adverse events observed in this study."

Reference:
Kalman DS, Feldman S, Feldman R, Schwartz HI, Krieger DR, Garrison R. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J. 2008 Apr 21;7:11.

University Health Industries Launches National Television Commercial Campaign

2008-04-28T10:12:00.000-07:00

"BOCA RATON, Fla.--(BUSINESS WIRE)--University Health Industries, Inc., (Pink Sheets:VRTN - News) is pleased to announce that it has launched a national television commercial campaign."

"University Health Industries has launched a national television campaign for Arthroleve™, a product that helps to alleviate joint pain and stiffness and promote overall joint health. The commercial for the Zenstral PMS™ product, which offers relief from many of the symptoms associated with premenstrual syndrome, is scheduled to follow. Both commercials were produced by UHI’s production company, Avalanche Creative, in New York."

For the full story: http://biz.yahoo.com/bw/080428/20080428005198.html?.v=1

UHI's product websites include: www.arthroleve.com and www.zenstralpms.com.

New blog site

2007-12-15T21:39:00.001-08:00

For those who prefer wordpress blog format, I've forwarded the posts from this blog as well as my Arthritis research update site to a single blog site

This site has some convenient features including a search function to allow you to search through posts for specific information.

Black Cohosh for hot flushes?

2007-12-14T11:18:00.000-08:00

Black Cohosh for hot flushes?

The results of a recent study suggest that black cohosh is more effective for reducing menopausal symptoms of hot flushes and night sweats than fluoxetine. However, fluoxetine was more effective in improving symptoms of depression.

"The objective of this study was to evaluate the efficacy of fluoxetine and black cohosh in the treatment of women with postmenopausal symptoms."

"At the end of the sixth month of treatment, black cohosh reduced the hot flush score by 85%, compared with a 62% result for fluoxetine. By the sixth month of the study, 40 women had discontinued the study--20 (33%) in the fluoxetine group and 20 (33%) in the black cohosh group. Compared with fluoxetine, black cohosh is more effective for treating hot flushes and night sweats. On the other hand, fluoxetine is more effective in improvements shown on Beck's Depression Scale."

Reference:
Oktem M, Eroglu D, Karahan HB, Taskintuna N, Kuscu E, Zeyneloglu HB. Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial. Adv Ther. 2007 Mar-Apr;24(2):448-61.

Gardasil vaccine trial results from New England Journal of Medicine

2007-12-12T11:59:00.000-08:00

Gardasil Vaccine?

Gardasil is a new vaccine for young women to help prevent cervical cancer and HPV which is made by the pharmaceutical giant, Merck. Here are the results of a recent clinical trial on the vaccine:

"BACKGROUND: A phase 3 trial was conducted to evaluate the efficacy of a prophylactic quadrivalent vaccine in preventing anogenital diseases associated with human papillomavirus (HPV) types 6, 11, 16, and 18."

"CONCLUSIONS: The quadrivalent vaccine significantly reduced the incidence of HPV-associated anogenital diseases in young women."

Reference
Garland SM, Hernandez-Avila M, Wheeler CM, Perez G, Harper DM, Leodolter S, Tang GW, Ferris DG, Steben M, Bryan J, Taddeo FJ, Railkar R, Esser MT, Sings HL, Nelson M, Boslego J, Sattler C, Barr E, Koutsky LA; Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) I Investigators. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med. 2007 May 10;356(19):1928-43.

For more information:

http://www.gardasil.com/

Omega-3 fatty acids and cancer

2007-12-12T07:39:00.000-08:00

Omega -3 fatty acids and cancer?

Though there are several health benefits of taking an omega-3 fatty acid supplement, this recent study suggests that cancer prevention may not be one of them:

"CONTEXT: Omega-3 fatty acids are purported to reduce the risk of cancer. Studies have reported mixed results."

"CONCLUSIONS: A large body of literature spanning numerous cohorts from many countries and with different demographic characteristics does not provide evidence to suggest a significant association between omega-3 fatty acids and cancer incidence. Dietary supplementation with omega-3 fatty acids is unlikely to prevent cancer."

Reference:
MacLean CH, Newberry SJ, Mojica WA, Khanna P, Issa AM, Suttorp MJ, Lim YW, Traina SB, Hilton L, Garland R, Morton SC. Effects of omega-3 fatty acids on cancer risk: a systematic review. JAMA. 2006 Jan 25;295(4):403-15.

Vitamin intake and breast cancer risk

2007-12-12T07:38:00.000-08:00

A new study suggests that vitamins B6 and B12 may reduce the risk of breast cancer, particularly in postmenopausal women.

"BACKGROUND: High intake of folate, vitamin B(6), and vitamin B(12) have been hypothesized to lower the risk for breast cancer. "

"CONCLUSIONS: In this population, high intakes of folate and vitamin B(12) were independently associated with decreased breast cancer risk, particularly among postmenopausal women."

Reference
Lajous M, Lazcano-Ponce E, Hernandez-Avila M, Willett W, Romieu I. Folate, vitamin B(6), and vitamin B(12) intake and the risk of breast cancer among Mexican women. Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):443-8.

Supplementation with Coenzyme q10, riboflavin, and niacin in breast cancer patients

2007-12-12T07:20:00.000-08:00

Results of a recent study:

"In breast cancer patients, it is not the primary tumour, but its metastases at distant sites that are the main cause of death. Circulating breast cancer tumour markers such as carcinoembryonic antigen (CEA) and carbohydrate antigen 15-3 (CA 15-3) are reliable indicators of impending relapse, in which an increasing tumour marker level is associated with a very likelihood of developing recurrence."

"In the present study, 84 breast cancer patients were randomized to receive a daily supplement of 100 mg coenzyme Q10 (CoQ10), 10 mg riboflavin and 50 mg niacin (CoRN) one dosage per day along with 10 mg tamoxifen (TAM) twice a day."

"Serum cytokine levels were elevated in untreated breast cancer patients (Group II) and significantly reduced after tamoxifen therapy for more than 1 year (Group III). When group III breast cancer patients were supplemented with CoRN for 45 days (Group IV) and 90 days (Group V) along with tamoxifen, a significant reduction in cytokine levels were observed (P < 0.05). Such a decrease in serum cytokine levels after CoRN supplementation in breast cancer patients may suggest good prognosis and efficacy of the treatment, and might even offer protection from metastases and recurrence of cancer."

Reference: Premkumar VG, Yuvaraj S, Vijayasarathy K, Gangadaran SG, Sachdanandam P. Effect of coenzyme Q10, riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy. Biol Pharm Bull. 2007 Feb;30(2):367-70.

Vitamin D supplementation may lower breast cancer risk

2007-12-12T07:18:00.000-08:00

Results from a recent study:

"Vitamin D, a prosteroid hormone with anti-proliferative and pro-differentiation activity, is thought to act as a cancer chemopreventive agent. This study evaluated the association between vitamin D intake and breast cancer risk among women in a large prospective cohort study. "

"Vitamin D intake of >800 IU/day appears to be associated with a small decrease in risk of breast cancer among postmenopausal women. Studies evaluating all sources of vitamin D, especially sun exposure, are needed to fully understand the association between vitamin D and breast cancer risk."

Reference
Robien K, Cutler GJ, Lazovich D. Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women's Health Study. Cancer Causes Control. 2007 Sep;18(7):775-82. Epub 2007 Jun 5.

Novel dietary supplement improves skin in post-menopausal women

2007-12-10T11:35:00.000-08:00

New study on supplement to improve skin:

"OBJECTIVE: The aim of the present study was to quantify the effects on skin in post-menopausal women of a novel dietary supplement (Imedeen Prime Renewal) that contained soy extract, fish protein polysaccharides, extracts from white tea, grape seed and tomato, vitamins C and E as well as zinc and chamomile extract."

"CONCLUSION: In summary, this novel dietary supplement, Imedeen Prime Renewal, provides improved condition, structure and firmness of the skin in post-menopausal women after 6 months."

Reference:

Skovgaard GR, Jensen AS, Sigler ML. Effect of a novel dietary supplement on skin aging in post-menopausal women. Eur J Clin Nutr. 2006 Oct;60(10):1201-6. Epub 2006 May 3.

Recent clinical trial on herbal formula containing black cohosh, dong quai, milk thistle... for menopausal symtoms

2007-12-10T11:09:00.000-08:00

"OBJECTIVE: To determine the efficacy and safety of the herbal formula Phyto-Female Complex (SupHerb, Netanya, Israel; ingredients: standardized extracts of black cohosh, dong quai, milk thistle, red clover, American ginseng, chaste-tree berry) for the relief of menopausal symptoms."

"CONCLUSION: Phyto-Female Complex is safe and effective for the relief of hot flushes and sleep disturbances in pre- and postmenopausal women, at least for 3 months' use."

Reference:
Rotem C, Kaplan B. Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study. Gynecol Endocrinol. 2007 Feb;23(2):117-22.

Technorati Tags: menopause, hot+flushes, black+cohosh

Natural treatments for menopause

2007-12-10T10:55:00.002-08:00

Natural treatments for menopause?

Though the results of the Herbal Alternatives for Menopause (HALT) study have yet to be published, I am sure that many women will be interested in the results—especially considering the recent safety concerns regarding Hormone Replacement Therapy.

Women were randomly assigned to: (1) black cohosh 160 mg daily; (2) multibotanical (50 mg black cohosh, alfalfa, chaste tree, dong quai, false unicorn, licorice, oats, pomegranate, Siberian ginseng, boron) four capsules daily; (3) multibotanical plus telephone counseling to increase dietary soy; (4) conjugated equine estrogen 0.625 mg +/- 2.5 mg medroxyprogesterone acetate; or (5) placebo.

Reference:

Newton KM, Reed SD, Grothaus L, Ehrlich K, Guiltinan J, Ludman E, Lacroix AZ. The Herbal Alternatives for Menopause (HALT) Study: background and study design. Maturitas. 2005 Oct 16;52(2):134-46.

Does dong quai have estrogenic effects in postmenopausal women?

2007-12-10T10:52:00.000-08:00

Dong quai for menopause?

This recent study suggests that Dong quai does not have estrogen-like effects.

"CONCLUSION(S): Used alone, dong quai does not produce estrogen-like responses in endometrial thickness or in vaginal maturation and was no more helpful than placebo in relieving menopausal symptoms" (Hirata et al, 1997).

Reference:
Hirata JD, Swiersz LM, Zell B, Small R, Ettinger B. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril. 1997 Dec;68(6):981-6.

Glucosamine FACS

2007-12-05T08:33:00.001-08:00

Zenstral PMS FACS

2007-12-05T08:02:00.001-08:00

1. What are the possible side effects of Zenstral PMS(TM)?

http://pmsresearch.blogspot.com/2007/10/what-are-possible-side-effects-of.html

2. How much Zenstral should I take?

http://pmsresearch.blogspot.com/2007/10/how-much-should-i-take-zenstral-pms.html

3. What evidence was used in formulating Zenstral PMS?

http://pmsresearch.blogspot.com/2007/10/what-evidence-was-used-in-formulating.html

4. How does Zenstral PMS work?

http://pmsresearch.blogspot.com/2007/10/how-does-zenstral-pms-work.html

5. What are the ingredients in Zenstral PMS?

http://pmsresearch.blogspot.com/2007/10/what-are-ingredients-in-zenstral-pms.html

6. Zenstral PMS description?

http://pmsresearch.blogspot.com/2007/10/zenstral-pms-description.html

pms pms relief zenstral pms dietary supplement premenstrual syndrome premenstrual dysphoric disorder pmdd

Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women.

2007-12-03T13:13:00.000-08:00

The results of a two recent, three year, randomized, placebo-controlled, prospective, indepent studies, were published in the journal, Menopause. The study authors concluded, "This analysis, from a large cohort of postemenopausal women, demonstrated for the first time that a pharmacological intervention for OA (osteoarthritis) has a disease-modifying effect in this particular population, the most frequently affected by knee OA.

References:
Bruyere O, Pavelka K, Royati LC, Deroisy R, Olejarova M, Gatterova J, Giacovelli G, Reginster JY. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3 year studies. Menopause. 2004 Mar-Apr; 11(2):138-43.

Natural Remedies for nausea and vomiting in early pregnancy?

2007-11-26T10:18:00.000-08:00

Nausea and vomiting are common complaints for many women during their pregnancy. A recent clinical involving over 126 pregnant women compared the efficacy of Ginger and Vitamin B6 (separately) to placebo. The pregnant women were randomly allocated to receive either 650 mg of ginger or 25 mg of vitamin B6 which were both administered three times per day for 4 days.

The study authors concluded that both Vitamin B6 as well as Ginger were effective in relieving the symptoms of naseau and vomiting in pregnant women. However, the study authors also concluded that ginger was more effective than Vitamin B6 in relieving theses symptoms in pregnant women. Side effects from ginger were reported to be minor and did not require any treatment.

Reference:

Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai. 2007 Jan;90(1):15-20.
Links

Technorati Tags: vitamin+b6, ginger, pregnancy, vomitting, dietary+supplement

Could your dry eyes be related to your menstrual cycle?

2007-11-26T07:47:00.000-08:00

Dry eyes are a very common symptom among many women today. New research suggests that dry eyes may be related to to women's monthly cyclical changes in hormone levels, in particular, related to their estrogen levels. This research suggests that the estrogen peak (seen above) which occurs during the follicular phase is associated with impairment of tear production resulting in ocular dryness and inflammation.

References:

Versura P, Fresina M, Campos EC. Ocular surface changes over the menstrual cycle in women with and without dry eye. Gynecol Endocrinol. 2007 Jul;23(7):385-90.

Comparison of estradiol levels of oral contraceptives on mood

2007-11-14T10:58:00.000-08:00

The results of a study comparing two different forms of triphasic oral contraceptive pills (OCP) on both mood and sexual interest were compared in a recent study which was published in the journal Contraception. Both pills had the same amount of progestin, but differing amounts of estradiol. The OCP with the lower amount of estradiol reducted free testosterone less and also resulted in a greater improvement in mood in a popluation of 60 university students.

"The lower EE (Ethinyl estradiol) pill reduced FT (free testosterone) less and was associated with greater improvement in premenstrual mood. A causal relation between these two effects is uncertain" (Greco et al, 2007).

References:
1. Greco T, Graham CA, Bancroft J, Tanner A, Doll HA. The effects of oral contraceptives on androgen levels and their relevance to premenstrual mood and sexual interest: a comparison of two triphasic formulations containing norgestimate and either 35 or 25 microg of ethinyl estradiol. Contraception. 2007 Jul;76(1):8-17. Epub 2007 May 23.

New research links oral contraceptives to artery clogging plaque

2007-11-07T11:01:00.000-08:00

As noted elsewhere on my site, birth control pills are one treatment option for women who suffer from the symptoms of PMS.

Data from a recent study was presented recently at the Amercian Heart Association. It's already well established that oral contraceptives or 'birth control pills' confer several risks including an increased risk of blod clots which can result in heart attacks or strokes--particularly in women who also smoke cigarettes.

Now, new data suggests that BCP's may also increase the risk of artery clogging plaques, even in women who no longer use the pill.

http://www.usatoday.com/news/health/2007-11-06-birth-control-heart_N.htm

Technorati Tags: birth+control+pill, oral+contraceptives, atherosclerosis, risks

Menstrual Migraines... Causes, symptoms, treatment...

2007-11-05T06:14:00.000-08:00

Many women report an increase in the frequency of migraine headaches in occurrence with the perimenstrual period. Many patients that I have seen used to call any severe headache they had a ‘migraine headache’. However, migraine headaches have some unique qualities which distinguish them from other headaches such as tension headaches.

What are some of the symptoms of migraine headaches?

1. Migraine headaches are most commonly on one side of your head vs tension headaches which are bilateral.
2. Migraine headaches often have a throbbing quality.
3. Migraine headaches are often accompanied by either sensitivity to noise, light, smell or various combinations of these.
4. Migraine headaches are often preceded by a prodrome which can include change in mood or fatigue.
6. Many patients who have migraine headaches often notice that it is preceded by an aura which can include blind spots in their vision called scotomas, or they may see flashing colorful lights.
7. Migraine headaches are often include Nausea/vomiting as a symptom.

What causes menstrual migraines?

Estrogens fluctuations, in particular, their premenstrual fall, are generally regarded as the main triggers of menstrual migraine.

Treatment options:

"Acute management of MM should initially be abortive and primarily sought with triptans. If this fails, short-term perimenstrual prophylaxis with NSAIDs, coxibs, triptans or ergotamine derivatives can be considered. Hormone manipulations, mainly application of percutaneous estradiol gel in PMP or administration of oral contraceptives in extended cycles, constitute an alternative approach for nonresponders" (Allais et al, 2007).

Summary from Allais et al:

Triptans--e.g. Sumatriptan--selective serotonin 5-HT1B/1D agonists.
NSAIDS--Non steroidal Anti-Inflammatory Drugs, e.g. naproxen, ibuprofen.
Ergoatamine--e.g. Cafergot (with caffeine).
Percutaneous Estradio gel for non-responders.

References:

Allais G, Castagnoli Gabellari I, De Lorenzo C, Mana O, Benedetto C. Menstrual migraine: clinical and therapeutical aspects. Expert Rev Neurother. 2007 Sep;7(9):1105-20.

Technorati Tags: menstrual+migraine, treatment, diagonsis, symptoms

Glucosamine use in pregnancy: an evaluation of pregnancy outcome.

2007-10-29T08:05:00.000-07:00

Is Glucosamine safe to use in pregnancy?

From a recent study published in the Journal of Womens Health, there's limited information to answer this question.

"CONCLUSIONS: These limited data suggest no increased risk for major malformations or other adverse fetal effects following the use of GLS during pregnancy."

Reference:
Sivojelezova A, Koren G, Einarson A. Glucosamine use in pregnancy: an evaluation of pregnancy outcome. J Womens Health (Larchmt). 2007 Apr

Vtiamin B6 May Reduce the Risk of Colorectal Cancer in Women

2007-10-29T07:57:00.001-07:00

For women who are concerned about their familial risk of colorectal cancer, taking a daily supplement of Vitamin B6 may be helpful.

"CONCLUSIONS: Our results suggest that vitamin B6 may be inversely associated with risk of colorectal neoplasia" ( Wei et al, 2005).

Wei EK, Giovannucci E, Selhub J, Fuchs CS, Hankinson SE, Ma J. Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women. J Natl Cancer Inst. 2005 May 4;97(9):684-92.

Technorati Tags: vitamin+b6, women, colorectal+cancer, reduce+risk, dietary+supplement

Vitex Agnus Castus for PMS

2007-10-26T07:55:00.000-07:00

"CONCLUSIONS: Dry extract of agnus castus fruit is an effective and well tolerated treatment for the relief of symptoms of the premenstrual syndrome" ( Schellenberg et al, 2001).

Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study. BMJ. 2001 Jan 20;322(7279):134-7.

www.zenstralpms.com

pms pms relief zenstral pms dietary supplement premenstrual syndrome premenstrual dysphoric disorder pmdd

Vitex agnus castus for premenstrual breast tenderness

2007-10-26T07:52:00.000-07:00

"Hence, it is concluded that dopaminergic compounds present in Vitex agnus castus are clinically the important compounds which improve premenstrual mastodynia and possibly also other symptoms of the premenstrual syndrome" (Wuttke et al, 2003).

Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D. Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications. Phytomedicine. 2003 May;10(4):348-57.

The patent pending Zenstral PMS(TM) formulation includes Vitex agnus castus extract. For a free trial box, click: http://www.zenstralpms.com/ today!

Technorati Tags: pms, pmdd, premenstrual+syndrome, zenstral+pms, pms+treatment, pms+diagnosis, pms+facs

Recent clinical trial on Vitamin B6 for Premenstrual Syndrome

2007-10-25T10:19:00.000-07:00

A recent clinical trial was published in Internation Journal of Gynaecology & Obstetrics which involved 160 university students from the same dormitory who had premenstrual syndrome. The outcomes on PMS symptoms were studied for two groups--those who received vitamin B6 and those received a placebo. The study authors concluded:

"Finally, there was a significant reduction in PMS severity following both forms of treatment and a comparison between the 2 groups also showed a significantly greater reduction in the pyridoxine group than in the placebo group."

Reference:

Kashanian M. Mazinani R. Jalalmanesh S. Pyridoxine (vitamin B6) therapy for premenstrual syndrome. [Journal Article. Randomized Controlled Trial] International Journal of Gynaecology & Obstetrics. 96(1):43-4, 2007 Jan.

Vitamin B6 is found in the patent-pending Zenstral PMS(TM) formulation. For a free sample of Zenstral PMS, click: http://www.zenstralpms.com/

Vitex Agnus Castus for PMS

2007-10-20T14:17:00.000-07:00

Premenstrual Syndrome (PMS) is a very common and potentially debilitating condition. My company makes a dietary supplment for the treatment of PMS. One of the key ingredients in our Zenstral PMS(TM) formulation is Vitex Agnus Castus. Here are the conclusions of a recent study on this ingredient:

"These results suggested for the first time that VAC acted as an agonist at the mu-opiate receptor, supporting its beneficial action in PMS" (Webster et al, 2006).

Webster DE, Lu J, Chen SN, Farnsworth NR, Wang ZJ. Activation of the mu-opiate receptor by Vitex agnus-castus methanol extracts: implication for its use in PMS. J Ethnopharmacol. 2006 Jun 30;106(2):216-21. Epub 2006 Jan 24.

Vitex Agnus Castus is part of the patent-pending Zenstral PMS(TM) formulation.
For a free sample of Zenstral PMS, visit http://www.zenstralpms.com/ today!

Technorati Tags: pms, pmdd, premenstrual+syndrome, zenstral+pms, pms+treatment, pms+diagnosis, pms+facs

Zenstral PMS available at Apple Health Store

2007-10-16T13:13:00.001-07:00

Buy 2, get 1 Free at Apple Health Store:

http://www.applehealthstore.com/shop/index.cfm?frm=details&piid=463&CFID=754965&CFTOKEN=74010547

Technorati Tags: pms, pmdd, premenstrual+syndrome, zenstral+pms, pms+treatment, pms+diagnosis, pms+facs

Birth control pills with low dose estrogen and PMS

2007-10-16T12:47:00.000-07:00

Birth control pills with low does estrogen...

A recent study compared two oral contraceptives with the same quantity of progestin, but differing amounts of estrogen on the effect on premenstrual mood symptoms (Greco et al, 2007). For women who suffer from PMS releted mood symptoms, the low estrogen BCP seems to be a better option.

"This study compared two oral contraceptives (OCs) with the same triphasic regimen of progestin (norgestimate 0.18, 0.215 and 0.25 mg) but differing doses of ethinyl estradiol (EE) - 25 and 35 microg EE - in their effects on androgens, mood and sexual interest in women starting on OCs" (Greco et al, 2007).

"The lower EE pill reduced FT less and was associated with greater improvement in premenstrual mood. A causal relation between these two effects is uncertain" (Greco et al, 2007).

In short, lower dose estrogen birth control pills were more effective at treating mood symptoms of premenstrual syndrome.

Reference:

Greco T, Graham CA, Bancroft J, Tanner A, Doll HA. The effects of oral contraceptives on androgen levels and their relevance to premenstrual mood and sexual interest: a comparison of two triphasic formulations containing norgestimate and either 35 or 25 microg of ethinyl estradiol. Contraception. 2007 Jul;76(1):8-17. Epub 2007 May 23.

Other Products from University Health Industries

2007-10-16T11:53:00.000-07:00

Arthroleve ULT(TM) is also available from University Health Industries for promoting joint health.

http://www.arthroleve.com/

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PMS Information Links

2007-10-16T11:35:00.000-07:00

PMS information links:

http://www.mayoclinic.com/health/premenstrual-syndrome/DS00134

http://www.medicinenet.com/premenstrual_syndrome/article.htm

University Health Industries, Inc. and University Lab Technologies, Inc. Announce Share Exchange

2007-10-16T11:33:00.001-07:00

"University Health Industries, Inc., formerly Virtual Innovations, Inc. (Company) (OTC:VRTN) announced today that the Company has completed a share exchange with the shareholders comprised of management owning a majority of the issued and outstanding shares of University Lab Technologies, Inc. (ULT), a Florida corporation engaged in the development, marketing and sale of proprietary, patent-pending nutraceutical products.Following such share exchange, the Company's executive offices are now located at ULT's corporate offices, 950 Peninsula Circle, Suite 3022, Boca Raton, Florida 33487.The Company's website address is http://www.universityhealthindustries.com/."

For the Full Story, click:

http://www.genengnews.com/news/bnitem.aspx?name=22848332

GnRH anaologs for treating PMS

2007-10-16T11:25:00.000-07:00

What is the effectiveness of using gonadotropin releasing hormone analogues (GnRHa) to treat PMS?

GnRH analogues work to stop menstrual periods by decreasing estrogen production. A recent meta-analysis published in the British Journal of Obstetrics and Gynecology concluded that GnRHa treatment appears to be an effective option in the management of PMS.4 Unfortunately, patients who take these analogues can experience several serious side effects, including menopausal type symptoms such as hot flashes, mood swings, vaginal dryness, and increased LDL cholesterol and bone loss.

SSRI's for PMS

2007-10-16T11:24:00.000-07:00

How effective are selective serotonin reuptake inhibitors (SSRI’s) for the treatment of PMS?

SSRI’s are a class of drugs used in the treatment of depression, anxiety, and personality disorders. Patients can experience many side effects from the use of these medications including weight changes, increase in anxiety, suicidal thoughts, and sexual dysfunction. A study published in the Cochrane Database concluded that there is very good evidence to support the use of selective serotonin reuptake inhibitors in the management of severe PMS. However, withdrawals due to side effects were 2.5 times more likely to occur in the treatment group than in the placebo group.3

What medical treatments are available for PMS and PMDD?

2007-10-16T11:23:00.000-07:00

there are four types of prescription drugs used for PMS/PMDD:

Antidepressants that act on serotonin, including fluoxetine, sertraline, and paroxetine.The FDA has recently ordered makers of several antidepressants to issue black box warnings that patients on these medications should be closely monitored for “clinical worsening, suicidality, or unusual changes in behavior.”
Agents that suppress ovulation, such as danazol, transdermal estradiol patches, and some oral contraceptives. These medications carry risks for serious side effects and can be very expensive.
Other psychotropics to reduce anxiety, such as alprazolam and other anxiolytic benzodiazepines. Since alprazolam has a very short half-life, there is a risk of addiction for patients who are started on this medication.
Spironolactone, a diuretic that is only available by prescription. It has proven effective in reducing premenstrual fluid retention, but doesn’t address the other symptoms of PMS.

How can I tell if I have PMS?

2007-10-16T11:22:00.002-07:00

According the American College of Obstetricians and Gynecologists (ACOG), you may have PMS if

Your PMS symptoms occur only during the last two weeks of your cycle.
the symptoms are sufficiently uncomfortable to impair your quality of life.
other disorders that may be mistaken for PMS have been excluded.

If you suspect you have PMS, ACOG recommends keeping a daily log of your symptoms for two or three consecutive months to help in diagnosis. It’s important to talk with your doctor to confirm your diagnosis and rule out other possible causes of your symptoms, such as depression, migraine headaches, seizure disorders, irritable bowel syndrome, chronic fatigue syndrome, or allergies.

What are the risks of PMD and PMDD?

2007-10-16T11:22:00.001-07:00

PMS and PMDD are not mere inconveniences. These conditions can adversely impact a woman’s personal, professional, and financial success. Women suffering from PMS are at increased risk of depression, absenteeism from work, strained relationships, reduced productivity, and worsening of medical conditions such as epilepsy, asthma, fibromyalgia, multiple sclerosis, or migraine headache during specific phases of their menstrual cycles.

What are the symptoms of PMS?

2007-10-16T11:21:00.000-07:00

Most women feel some discomfort before their periods. But if you have PMS, you may feel so anxious, depressed, or uncomfortable that you can't cope at home or at work. Common symptoms of PMS include:

Physical Symptoms

Breast tenderness (mastodynia)
Cramping
Swollen hands or feet
Headaches
Weight gain
Bloated abdomen
Constipation
Joint pain
Fatigue
Acne

Psychological Symptoms

Irritability
Angry outbursts
Low self-esteem
Anxiety
Confusion
Difficulty concentrating
Mood swings
Crying spells
Decreased libido
Depression

Symptoms usually stop or taper off soon after your period begins, and you may be symptom free until about two weeks before your next period.

What causes PMS?

2007-10-16T11:20:00.001-07:00

Though the exact cause of PMS is not completely understood, it appears that the hormones progesterone, estrogen and testosterone are involved, along with changes in the level of the brain chemical serotonin. Nutritional deficiencies in magnesium or vitamin B6, hormonal changes, neurotransmitter activity, diet, and stress have all been implicated in the etiology of PMS.1,2

www.zenstralpms.com for a free pms trial box!

Technorati Tags: pms, pmdd, premenstrual+syndrome, zenstral+pms, pms+treatment, pms+diagnosis, pms+facs

What are PMS and PMDD?

2007-10-16T11:19:00.000-07:00

Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), a more severe form of PMS, are both very common and potentially debilitating conditions from which many women suffer. Hormonal changes following ovulation trigger a group of disruptive symptoms that appear approximately 14 days before your period. PMS and PMDD affect an estimated 40 million women in the United States, with more than 5 million requiring medical treatment.

www.zenstralpms.com for a free sample!

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New smoking cessation treatment from Pfizer

2007-10-16T11:11:00.001-07:00

Does Chantix work to help you quit smoking?

Two recent studies were published in the Journal of American Medical Association about a new drug for smoking cessation (Gonzales et al, 2006; Jorenby et al 2006). Unlike other approved treatments for smoking cessation including nictotine replacement therapy, or selectively inhibit the reuptake of dopamine (Bubrorpion), Chantix is a partial agonist of the alpha 4 Beata 2 nictotinic acetylcholine receptor.In the study both of these studies, Chantix's efficacy exceeded buproprion SR and placebo (Jorenby et al, 2007).

During the last four weeks of treatment, 43.9% of participants in the varenicline (Chantix) group were abstinent from smoking compared with 17.6% and 29% in the placebo and buprioprion SR groups respectively.

In short, the participants in this study who took Chantix were more than twice as likely to quit smoking than those who took a placebo. Further, more participants who took Chantix quit smoking than those who took Zyban.

References

Gonzales D, Rennard SI, Nides M, Oncken C, Azoulay S, Billing CB, Watsky EJ, Gong J, Williams KE, Reeves KR; Varenicline Phase 3 Study Group. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial. JAMA. 2006 Jul 5;296(1):47-55.

Jorenby DE, Hays JT, Rigotti NA, Azoulay S, Watsky EJ, Williams KE, Billing CB, Gong J, Reeves KR; Varenicline Phase 3 Study Group. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA. 2006 Jul 5;296(1):56-63.

To view the Pfizer website for Chantix, click here:

http://www.chantix.com/

Is bright light therapy effective for treating the depression associated with premenstrual dysphoric disorder?

2007-10-16T11:04:00.001-07:00

Is bright light therapy effective for treating the depression associated with premenstrual dysphoric disorder?

Light therapy consists of exposure to full-spectrum light for a prescribed amount of time. A recent meta-analysis of bright light therapy published in the American Journal of Obstetrics and Gynecology concluded that “the current evidence justifies neither enthusiastic dissemination nor confident rejection of this therapeutic modality.”5

Essentially, this suggests that more research is required to study the potential benefit of this treatment for PMS. However, given the relative safety of this type of therapy, it may be worth trying for those who suffer from PMS. Talk to your doctor before starting any new therapy.

Reference:

Krasnik C, Montori VM, Guyatt GH, Heels-Ansdell D, Brusse JW; Medically Unexplained Syndromes Study Group. The effect of bright light therapy on depression associated with premenstrual dysphoric disorder. Am J Gynecol. 2005 Sep;193(3 Pt 1):658-61.

Using the daily record of severity of problems as a screening instrument for premenstrual syndrome.

2007-10-16T11:02:00.000-07:00

Current guidelines for the diagnosis of premenstrual disorders require prospective daily symptom charting for two cycles. This can be quite laborious and is rarely done in clinical practice. A new screening tool has recently been studied which would allow women who are likely to have PMS to be further evaluated.

"A cohort of 697 women kept daily symptom ratings using the Daily Record of Severity of Problems (DRSP). The DRSP includes 21 symptom items grouped within 11 domains. DRSP scores on the first day of menses were calculated using the sum of all 21 items (standard method), the sum of the highest rated items within each domain (alternative method), and the sum of seven items derived from modeling" (Borenstein et al, 2007)."The DRSP administered on the first day of menses is an acceptable screening instrument to identify women who may have PMS" (Borenstein et al, 2007).

"In conclusion, a screening procedure for PMS based on either 21-item or seven-item DRSP symptom ratings on the first day of menses was found to have acceptable test characteristics. These preliminary findings support the use of the DRSP for the identification of women who are most likely to benefit from a more thorough diagnostic evaluation" (Borenstein et al, 2007).

Reference:
Borenstein JE, Dean BB, Yonkers KA, Endicott J. Using the daily record of severity of problems as a screening instrument for premenstrual syndrome. Obstet Gynecol. 2007 May;109(5):1068-75

What can I do to manage my PMS symptoms?

2007-10-16T11:00:00.000-07:00

What can I do to manage my PMS symptoms?

Women can often manage the symptoms of premenstrual syndrome by making changes in the way they eat, exercise, and approach their daily lives. To reduce your discomfort, try implementing as many of the suggestions below as you can.

Dietary Tips for Controlling PMS

Eat smaller, more frequent meals to reduce bloating and the sensation of fullness.
Eat complex carbohydrates such as whole grain breads, pasta, and cereals.
Cut back on sugar and fat in your diet.Avoid salt for the last days before your period to reduce bloating and fluid retention.
Avoid caffeine intake to feel less tense and irritable.Avoid alcoholic beverages. Consuming alcohol before your period can make you feel more depressed.
Choose foods rich in calcium.Increase consumption of dietary fiber.

Lifestyle Tips for Controlling PMS

Get aerobic exercise.
Regular daily exercise will help improve your overall health and can alleviate symptoms such as fatigue and a depressed mood.
Ensure adequate sleep—about eight hours per night.Attempt to schedule stressful events for the week after your period.Maintain a regular schedule of meals, bedtime, and exercise.
Practice deep-breathing exercises to help reduce headaches, anxiety, or trouble sleeping.
Avoid smoking cigarettes.

Visit: www.zenstralpms.com for a free trial box!

Zenstral PMS Scientific References

2007-10-16T10:57:00.000-07:00

References for Zenstral PMS ingredients...

1 Mortola J. Premenstrual syndrome-pathophysiologic considerations. NEngl J Med. 1998; 338:256-7.

2 Chrousos GP, Torpy DJ, Gold PW. Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: Clinical implications. Ann Intern Med. 1998;129:229-40.

3 Wyatt KM, Dimmock PW, O’Brien PM. Selective serotonin reuptake inhibitors for premenstrual syndrome. Cochrane Database Syst Rev. 2002;(4):CD 001396.

4 Wyatt KM, Dimmock PW, Ismail KM, Jones PW, O’brien PM. The effectiveness of GnRHa with and without ‘add-back’ therapy in treating premenstrual syndrome: a meta analysis. BJOG, 2004 Jun;111(6):585-93.

5 Krasnik C, Montori VM, Guyatt GH, Heels-Ansdell D, Brusse JW; Medically Unexplained Syndromes Study Group. The effect of bright light therapy on depression associated with premenstrual dysphoric disorder. Am J Gynecol. 2005 Sep;193(3 Pt 1):658-61.

6 Merz PG, Gorkow C, Schordter A, Rietbrock S, Sider C, Loew D, Dericks–Tan JSE, Taubert HD. The effects of special Agnus castus extract (BP 109E1) on prolactin secretion in healthy male subjects. Exp Clin Endocrinol Diabetes. 1996;104:447-53.

7 Brugisser R, Burkard W, Simmen U, Schaffner W. Untersuchungen an Opiod-Rezeptorin mit Vitex agnus-castus L. Z Phytother. 1999;20:140-58.

8 Samochowic L, Glaesmer R, Samochowic J. EifluBvon Monchspfeffer auf die konzentration von beta-Endorphin im Serum weiblicher Ratten. Arztez Naturheilverfahren. 1998;39:213-215.

9 Rosenstein DL, Elin RJ, Hosseini JM, et al. Magnesium measures across the menstrual cycle in premenstrual women. Biol Psychiatry. 1994;35:557-61.

10 Schindler R, Thoni H, Classen HG. The role of magnesium in the generation and therapy of benign muscle cramps. Combined in vivo/in vitro studies on rat phrenic nerve-diaphragm preparations. Arneimittel-Forschung. 1998;48:161-66.

11 Schellenberg, et al. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomized, placebo controlled study. BMJ. 2001;322;134-7

12 Berger D, Schaffner W, Schrader E, Meier B, Brattstrom A. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS). Arch Gynecol Obstet. 2000; 264:150-53.

13 Atmaca M, Selahattin K, Texcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Human Psychopharmacol Clin Exp. 2003;18:191-5.

14 Blumenthal M, Busse WR, Goldberg A, et al. The complete German Commission E. monographs: therapeutic guide to herbal medicines. Austin TX. American Botanical Council. 1998, p1694.

15 De Souza M, Walker A, Robinson P, Bolland K. A synergistic effect of daily supplement for 1 month of 200mg magnesium plus 50mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. Journal of Womens Health & Gender-Based Medicine. 2000 Mar;9(2)131-3.

16 Wyatt K, Dimmock P, Jones P, Shaughn O’brien PM. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systemic review. BMJ. 1999; 318:1375-81.

17 Daniele C, Thompson J, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf. 2005;28(4):319-32.

18 Walker A, De Souza M, Vickers M, Abeyasekera S, Collins M, Trinca L. Magnesium supplementation alleviates premenstrual symptoms of fluid retention. Journal of Women’s Health. 1998 Nov;7(9):1157-65.

19 Proctor M, Murphy P. Herbal dietary therapies for primary and secondary dysmenorrhoea (Cochrane review). The Cochrane Library, Issue 2, 2002. Oxford: update software.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

www.zenstralpms.com

Who is University Health Industries, Inc?

2007-10-16T10:55:00.002-07:00

http://www.universityhealthindustries.com/

Every year, research labs around the globe identify and test natural compounds with the potential to improve human health—yet more than 98% of these discoveries are never commercialized for the benefit of the public.University Health Industries, Inc. (UHI), in collaboration with universities worldwide, researches natural compounds with clinically proven efficacy, identifies those with the greatest potential for enhancing human life, then develops them into patented nutraceutical products for treating common chronic ailments.Our mission is to make the latest clinical discoveries in natural compounds available to consumers, delivered in patented pharmaceutical-grade formulations with guaranteed quality and potency.UHI is a proud American company with offices and manufacturing facilities in Boca Raton, Florida.

All of our products are GMP-approved and made in the United States to ensure they adhere to standards the American public can trust. What other nutraceuticals are available from UHI?UHI will introduce three new products in the coming weeks , each developed with the same quality and efficacy standards as:

Zenstral PMS™
Arthroleve ULT™ for bone and joint pain†
Premium SAMe ULT™ for mood support†
Cold & Flu RMD™ for immune system support and relief from the common cold†

Our physicians and pharmacologists are hard at work creating additional evidence-based nutraceutical products.

Visit the UHI Web site at http://www.universityhealthindustries.com/ for updates, or request new product announcements by email at www.zenstralpms.com.We welcome your feedback. Please contact us at 800-517-7734 or send an email to customercare@ultlabs.com with your suggestions, questions, and comments.

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What is the NPA TruLabel Program?

2007-10-16T10:55:00.001-07:00

The Natural Products Association (NPA) TruLabel program is the industry's most expansive and successful self-regulatory program.University Health Industries and other NPA members voluntarily pay for random monitored tests of their products by independent laboratories. If a test reveals any deficiency in product quality or accuracy in labeling, NPA immediately alerts the member company and expects it to take corrective action. NPA revokes the membership of any company that does not comply.What is your guarantee?University Health Industries’ products are backed by our 100% money-back guarantee for first-time orders. If for any reason you are not completely satisfied with your order, simply return it within 30 days and we'll issue you a full refund of your purchase price, less shipping and handling.

What are the possible side effects of Zenstral PMS?

2007-10-16T10:54:00.001-07:00

What are the possible side effects of Zenstral PMS?

No serious side effects have been reported for the ingredients in Zenstral PMS™. Data from clinical trials, post-marketing surveillance studies, spontaneous reporting systems, manufacturers, and herbalist organizations indicate that the compounds in Zenstral PMS™ are generally well tolerated, and that any adverse events following VAC treatment are mild and reversible.17

Possible side effects include nausea, gastrointestinal discomfort, headache, or pruritus.11,12,13,15,16,17,18Consult a physician if you experience any of these side effects or use this product longer than six months.

Discontinue use and consult a physician if an allergic reaction occurs.No drug interactions have been reported. However, because of Zenstral’s mode of action, consult your physician before use if you are taking dopamine-related medications.

When will Zenstral PMS(TM) Start to work?

2007-10-16T10:53:00.002-07:00

When will it start to work?

With daily use, Zenstral™ will reach therapeutic levels in your system within three to four weeks, so you should feel relief by the second cycle. In contrast, prescription antidepressants take at least a month to start working and don’t address the physical symptoms of PMS.

How much should I take--Zenstral PMS?

2007-10-16T10:53:00.001-07:00

How much Zenstral PMS should I take?

The typical dosage is one caplet twice daily.

Take Zenstral™ every day of the month, not only when you’re having symptoms. It needs to reach and maintain therapeutic levels in the body to work.

What evidence was used in formulating Zenstral PMS™?

2007-10-16T10:52:00.001-07:00

What evidence was used in formulating Zenstral PMS™?

Below is a representative sample of the scientific evidence used in formulating Zenstral PMS™:

Vitex Agnus Castus Extract (VAC)

A recent double-blind, randomized controlled trial published in the British Medical Journal demonstrated a 52 percent reduction in PMS symptoms in women treated with dry extract of agnus castus fruit.11 Similar results were obtained in another study published in the Archives of Gynecology and Obstetrics.12Another recent study found Vitex agnus castus extract to be as effective as fluoxetine for the treatment of PMDD, a more severe form of PMS. The authors reported that 57.9 percent of patients responded to VAC extract in the treatment of this disorder, and also found that VAC extract was more effective than fluoxetine in treating the physical symptoms of PMDD.13German health authorities have approved the use of chasteberry for three gynecological conditions: menstrual cycle irregularity, premenstrual syndrome (PMS), and mastodynia (breast pain).14

Magnesium

A recent randomized, double-blind crossover study concluded that magnesium works synergistically with vitamin B6 to relieve anxiety symptoms associated with PMS.15

Vitamin B6

The British Medical Journal did a meta-analysis of vitamin B6 in the treatment of PMS and concluded that it was likely to be beneficial in treating premenstrual symptoms and premenstrual depression.16 Who should not take Zenstral PMS™?

Consult a physician before use if you are pregnant, nursing, taking birth control pills, have a hormone-sensitive medical condition such as breast cancer, or are taking dopamine-related medications.

What is a meta-analysis?

2007-10-16T10:51:00.003-07:00

What is a meta-analysis?

A meta-analysis involves collecting data from many similar research studies, then analyzing the pooled data for statistical significance.

What is evidence-based medicine?

2007-10-16T10:51:00.001-07:00

What is evidence-based medicine?

Evidence based medicine (EBM) involves examining a broad spectrum of evidence—such as meta-analyses, systematic reviews of existing research, randomized controlled trials, cohort studies, and other methods of inquiry—to make decisions about patient care and treatment.EBM is rapidly becoming the new paradigm in health care, replacing the older authority-based model where the value of a medical treatment (and sometimes its availability) was based on the work of a limited number of experts.To learn more about evidence based medicine, a non-profit organization called the Cochrane Collaboration (www.cochrane.org) is an excellent place to begin.

How does Zenstral PMS™ work?

2007-10-16T10:46:00.000-07:00

How does Zenstral PMS™ work?

The natural compounds in Zenstral work on many of the biochemical mechanisms that contribute to PMS:†

Vitex Agnus Castus Extract (VAC): VAC acts on the hypothalamic-pituitary-adrenal (HPA) axis, a set of complex interactions between three hormone-producing organs. It also reduces stress-induced prolactin levels by simulating the effects of dopamine in the brain (dopamine agonist). In addition, VAC has been found to elevate beta-endorphin and opiod levels, naturally occurring substances that decrease pain and create a feeling of calm and well-being.

Magnesium: Low levels of red-cell magnesium have been correlated with symptoms of PMS. This is the rationale for supplementation with magnesium and has resulted in a number of studies on magnesium supplementation in women suffering from PMS.

Vitamin B6: Also called pyroxidine, vitamin B6 has a positive effect on levels of neurotransmitters such as serontonin, norepinephrine, histamine, dopamine, and taurine.

What are the ingredients in Zenstral PMS™?

2007-10-16T10:45:00.001-07:00

What are the ingredients in Zenstral PMS™?

Each caplet contains 20 mg of Vitex agnus castus (.3% casticin), 200 mg of magnesium oxide (MgO), and 50 mg of vitamin B6 (pyroxidine). The Vitex agnus castus (VAC) compound used in Zenstral is casticin, a flavonoid from the chasteberry. This is the same substance used in the clinical studies that show Vitex agnus castus to be effective. Nearly all other products on the market standardize to agnuside, a terpene compound from the chasteberry tree.

Who should take Zenstral PMS™?

2007-10-16T10:44:00.000-07:00

Who should take Zenstral PMS™?

Zenstral PMS™ is recommended for women suffering from:

1. General PMS-related symptoms
2. Cyclical mood symptoms of PMS including irritability, tension, depression
3. Lower back and joint pain associated with PMS
4. Fluid retention associated with PMS
5. Breast tenderness associated with PMS

visit: zenstralpms.com for a free trial box!

What is Zenstral PMS™?

2007-10-16T10:43:00.001-07:00

What is Zenstral PMS™?

Zenstral PMS™ is an innovative blend of natural compounds that are scientifically proven to reduce the symptoms of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). Unlike other PMS treatments, Zenstral addresses both the physical and psychological symptoms of PMS/PMDD in one convenient product, without the risk of dangerous side effects. Using the principles of evidence based medicine, our physicians and pharmacologists formulated Zenstral PMS™ after months of reviewing the results of university research studies worldwide. The result is a powerful nutraceutical that is as effective as other PMS remedies—and safer.†

visit: zenstralpms.com for a free trial!

Zenstral PMS Description

2007-10-16T10:40:00.000-07:00

Natural PMS Cure

Created by nature… proven by science.
100% Pharmaceutical Grade Zenstral PMS™
Natural, scientifically proven relief for women who suffer from physical and emotional symptoms of PMS or PMDD

For women suffering from symptoms of PMS
For women suffering from breast tenderness
For women with PMS associated fluid retention

Find out how Zenstral PMS can relieve the pain and stress of the symptoms of PMS and PMDD!

Powerful Natural Pharmacology Formulated by physicians and pharmacologists using evidence based medicine and the results of university research worldwide, Zenstral PMS™ is an innovative blend of natural compounds scientifically proven to reduce the symptoms of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD).†

Typical PMS treatments address either physical or psychological symptoms, but not both. And many of these common remedies, including birth control pills, antidepressants, pain relievers, diuretics, and other drugs, carry serious risks and side effects.Zenstral PMS™ offers you safe, effective relief from physical and psychological PMS symptoms in one convenient product—and it’s just a click away. Reserve your risk free trial of Zenstral PMS™ today.

How Zenstral Works
Zenstral PMS™ is a patent-pending blend of natural compounds including Vitex agnus castus (chasteberry), magnesium oxide, and vitamin B6. University research studies worldwide have shown these compounds safely and effectively relieve both the physical and psychological symptoms of PMS and PMDD.†

For a free trial box: zenstralpms.com

Zenstral PMS Testimonial

2007-10-16T10:39:00.001-07:00

Satisfied Zenstral PMS customer

Here is an email that I recently received from one of our satisfied Zenstral PMS customers...

“I want to thank you for all of your help. I have had the most terrible PMS with every symptom possible. Zenstral PMS has made all the difference! I have none of the symptoms: no headache, cramps, irritability, mood swings, or aches. This works! Thanks so much for this product!"

-Debbie W, North Carolina.

Natural premenstrual treatment

2007-10-16T10:38:00.000-07:00

Zenstral PMS product features

1. Medical Doctor formulated.

2. Slick Cap Technology(TM) to ensure ease of swallowing.

3. Individual foil blister packs.

4. Patent-pending formulation.

5. Made 100% in USA in FDA approved facility

6. Clinically-proven ingredients.

Visit zenstralpms.com for more information