Vitex Agnus Castus for PMS

"CONCLUSIONS: Dry extract of agnus castus fruit is an effective and well tolerated treatment for the relief of symptoms of the premenstrual syndrome" ( Schellenberg et al, 2001).


Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study. BMJ. 2001 Jan 20;322(7279):134-7.

www.zenstralpms.com

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Recent clinical trial on Vitamin B6 for Premenstrual Syndrome

 A recent clinical trial was published in Internation Journal of Gynaecology & Obstetrics which involved 160 university students from the same dormitory who had premenstrual syndrome. The outcomes on PMS symptoms were studied for two groups--those who received vitamin B6 and those received a placebo. The study authors concluded:

"Finally, there was a significant reduction in PMS severity following both forms of treatment and a comparison between the 2 groups also showed a significantly greater reduction in the pyridoxine group than in the placebo group."

Reference:

Kashanian M. Mazinani R. Jalalmanesh S. Pyridoxine (vitamin B6) therapy for premenstrual syndrome. [Journal Article. Randomized Controlled Trial] International Journal of Gynaecology & Obstetrics. 96(1):43-4, 2007 Jan.

Vitamin B6 is found in the patent-pending Zenstral PMS(TM) formulation. For a free sample of Zenstral PMS, click: http://www.zenstralpms.com/

What evidence was used in formulating Zenstral PMS™?

What evidence was used in formulating Zenstral PMS™?

Below is a representative sample of the scientific evidence used in formulating Zenstral PMS™:

Vitex Agnus Castus Extract (VAC)

A recent double-blind, randomized controlled trial published in the British Medical Journal demonstrated a 52 percent reduction in PMS symptoms in women treated with dry extract of agnus castus fruit.11 Similar results were obtained in another study published in the Archives of Gynecology and Obstetrics.12Another recent study found Vitex agnus castus extract to be as effective as fluoxetine for the treatment of PMDD, a more severe form of PMS. The authors reported that 57.9 percent of patients responded to VAC extract in the treatment of this disorder, and also found that VAC extract was more effective than fluoxetine in treating the physical symptoms of PMDD.13German health authorities have approved the use of chasteberry for three gynecological conditions: menstrual cycle irregularity, premenstrual syndrome (PMS), and mastodynia (breast pain).14

Magnesium

A recent randomized, double-blind crossover study concluded that magnesium works synergistically with vitamin B6 to relieve anxiety symptoms associated with PMS.15

Vitamin B6

The British Medical Journal did a meta-analysis of vitamin B6 in the treatment of PMS and concluded that it was likely to be beneficial in treating premenstrual symptoms and premenstrual depression.16 Who should not take Zenstral PMS™?

Consult a physician before use if you are pregnant, nursing, taking birth control pills, have a hormone-sensitive medical condition such as breast cancer, or are taking dopamine-related medications.